Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Not for human use. Keep out of reach of children. Consult a physician in case of accidental ingestion by humans.
Proin® may cause increased thirst; therefore, provide ample fresh water. Proin® should be stored out of reach of dogs in a secured area. Use in dogs with incontinence due to a urinary tract infection will mask symptoms. Proin® is not effective in dogs with incontinence due to neurologic disease or malformations. Proin® may cause hypertension; therefore, use with caution in dogs with pre-existing heart disease, hypertension, liver disease, kidney insufficiency, diabetes, glaucoma, and conditions with a predilection for hypertension. Use with caution in dogs receiving sympathomimetic drugs, tricyclic antidepressants, or monoamine oxidase inhibitors as increased toxicity may result. Use with caution in dogs administered halogenated gaseous anesthetics as this may increase the risk of cardiac arrhythmias. A laboratory study on human blood revealed that PPA used in conjunction with aspirin may potentiate decreased platelet aggregation.
The safe use of Proin® in dogs used for breeding purposes, during pregnancy or in lactating bitches, has not been evaluated.