Store at controlled room temperature 15°- 30° C (59° - 86° F).
Do not use in viral infections. Prednisone, like methylprednisolone,
is contraindicated in animals with peptic ulcer, corneal ulcer, and
Cushingoid syndrome. The presence of diabetes, osteoporosis,
predisposition to thrombophlebitis, hypertension, congestive heart
failure, renal insufficiency, and active tuberculosis necessitates
carefully controlled use. Some of the above conditions occur only
rarely in dogs but should be kept in mind.
Prednisone is similar to methylprednisolone in regard to kinds of
side effects and metabolic alterations to be anticipated when treatment
is intensive or prolonged. In animal patients with diabetes mellitus,
use of prednisone may be associated with an increase in the insulin
requirement. Negative nitrogen balance may occur, particularly in
animals that require protracted maintenance therapy; measures to
counteract persistent nitrogen loss include a high protein intake and
the administration, when indicated, of a suitable anabolic agent.
Excessive loss of potassium, like excessive retention of sodium, is not
likely to be induced by effective maintenance doses of prednisone.
However, these effects should be kept in mind and the usual regulatory
measures employed as indicated. Ecchymotic manifestations in dogs may
occur. If such reactions do occur and are serious, reduction in dose or
discontinuance of prednisone therapy may be indicated.
Side effects, such as SAP and SALT enzyme elevations, weight loss,
anorexia, polydipsia and polyuria have occurred following the use of
synthetic cortico-steroids in dogs. Vomiting and diarrhea (occasionally
bloody) have also been observed. Cushing's syndrome in dogs has been
reported in association with prolonged or repeated steroid therapy.
Since prednisone, like methylprednisolone, suppresses endogenous
adrenocortical activity, it is highly important that the animal
patient receiving prednisone be under careful observation, not only
during the course of treatment but for some time after treatment is
terminated. Adequate adrenocortical supportive therapy with cortisone
or hydrocortisone, and including ACTH, must be employed promptly if the
animal is subjected to any unusual stress such as surgery, trauma, or