Free standard ground shipping on $100 or more! Details »
close ×

Get free standard ground shipping* on orders of $100 or more.

* FREE STANDARD GROUND SHIPPING within the contiguous United States on qualifying orders of $100 or more. Certain items marked free shipping, perishable, drop ship, special order, and orm-d are not included in the $100 total. Handling fee of $1 applies to all orders. Oversize fees are listed on product page. Call for drop ship fees. Express delivery is available upon request. Perishable items (including vaccines and some medications) can only be shipped overnight, and are not eligible for free standard ground shipping. Other restrictions may apply.

close ×
tour LVS
Shop our newest digital catalog!
Diphenhydramine
Diphenhydramine

Diphenhydramine

Part Number:8898|

Manufacturer |

Varies
  • Antihistamine
  • Relieves respiratory allergies and itching
  • Used to prevent motion sickness in dogs
  • Competitively inhibits histamine binding at the H1 receptors

Manufacturer Varies, Product Label may be different than shown.

Your Price: $24.99

Choose Options

Size
50 mg x 1000 ct
In Stock

Diphenhydramine

Diphenhydramine is an antihistamine that competitively inhibits histamine binding at the H1 receptors. Antihistamines do not block the release of histamine but compete for uptake at the receptors on sensitive cells in the respiratory tract, intestines, blood vessels and skin.

Diphenhydramine is used in companion-animal practice to treat allergies and atopy primarily in dogs. Antihistamines alone can control pruritis in 20-40% of atopic dogs. If antihistamines are unable to control all of the allergic signs, they may be used with corticosteroids, allowing use of a lower dose of the corticosteroids. The sedative effects seen with diphenhydramine use also may help with agitation associated with allergic symptoms. Antihistamines should not be used within a week of skin testing for allergies.

Diphenhydramine also may be used as an antiemetic and frequently is used to prevent motion sickness in dogs. H1 histaminergic receptors play a role in the emetic response associated with motion sickness in dogs (but not in cats). Diphenhydramine will cause some central nervous system (CNS) depression and sedation, although the sedative effects may diminish with time. When using oral diphenhydramine for motion sickness, it should be given 30 to 60 minutes before traveling.

H1 blockers such as diphenhydramine and H2 blockers such as ranitidine or cimetidine are used in dogs prior to surgical excision of mast cell tumors in order to prevent some of the effects of massive histamine release due to mast cell de-granulation. These drugs generally are continued during the recovery period in order to improve wound healing.

Diphenhydramine also is used to treat neurotoxicity or extrapyrimidal effects due to phenothiazines, metoclopramide and tremors due to organophosphate or carbamate poisoning. Chlorpheniramine is the antihistamine-of-choice for pruritis, alopecia and motion sickness in cats. Manufacturer may vary from product shown.

Manufacturer may vary from product shown.

SHOP OUR DIGITAL CATALOG »
Information
Categories