Denosyl for Medium Dogs

Administration of Denosyl Tablets

Because the tablet must be kept intact to prevent destruction by moisture, administration range is based on the nearest whole-tablet. The chart below is provided as a guide for administration. Daily administration may also be calculated based on 20 mg/kg of body weight and rounded to the closest tablet size or combination of sizes.

For optimal absorption, tablets should be given on an empty stomach, at least one hour before feeding, as the presence of food decreases the absorption of S-Adenosylmethionine. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.^6,7 If the pet is to receive more than one tablet daily, the total number of tablets may be divided between morning and evening for ease of administration. For example, a daily administration of three tablets could be divided into two tablets in the morning and one tablet in the evening.

Denosyl Canine Daily* Administration Guide

For Cats and Small Dogs (90 mg)

For Medium Dogs (225 mg)

For Large Dogs (425 mg)

*The number of tablets can be gradually reduced or increased at any time depending on the pet's needs.

Many pets are maintained long-term on every-other-day or every-third-day administration.

Storage

Store in a cool dry place not to exceed 86° F. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat.

S-Adenosylmethionine 225 mg

Store in a cool dry place. Keep tablets in original blister pack until used. Tablets are sensitive to moisture and extreme heat and should not be split or crumbled.

References

1. Center SA, Warner K, Hoffman WE, et al. Am J Vet Res 2005;66:330-341.
2. Center SA, Randolph JF, Warner K, et al. J Vet Intern Med 2005;19:303-314.
3. Webster CRL, Boria P, Usechak P, et al. Vet Therapeutics 2002;3:474-484.
4. McCool J, Johnston A, Webster CRL. In Proceedings. 21st Annual ACVIM Forum 2003;abstract #134.
5. Center SA. In Proceedings. 18th Annual ACVIM Forum 2000;550-552.
6. Westfall DS, Twedt DC, Steyn PF, et al. J Vet Intern Med 2001;15(5):467-470.
7. Graham JP, Lipman AH, Newell SM, Roberts GD. Am J Vet Res 2000;61(6):655-657.