cephapirin sodium
FOR INTRAMAMMARY INFUSION DESCRIPTION
Each 10 mL disposable syringe contains 200 mg of cephapirin activity in a stable peanut oil gel. This product was manufactured by a non-sterilizing process.
Store at controlled room temperature 15° to 30°C (59° to 86°F); avoid excessive heat. ACTION
Cephapirin is bactericidal to susceptible organisms; it is known to be highly active against Streptococcus agalactiae and Staphylococcus aureus including strains resistant to penicillin.
To determine the susceptibility of bacteria to cephapirin in the laboratory the class disc Cephalothin Susceptibility Test Discs 30 mcg should be used. INDICATIONS
ToDAY (cephapirin sodium) for Intramammary Infusion should be used at the first signs of inflammation or at the first indication of any alteration in the milk. Treatment is indicated immediately upon determining by C.M.T. or other tests that the leucocyte count is elevated or that a susceptible pathogen has been cultured from the milk.
ToDAY for Intramammary Infusion has been shown to be efficacious in the treatment of mastitis in lactating cows caused by susceptible strains of Streptococcus agalactiae and Staphylococcus aureus including strains resistant to penicillin. DOSAGE AND DIRECTIONS FOR USE
Infuse the entire contents of one syringe (10 mL) into each infected quarter immediately after the quarter has been completely milked out. Repeat once only in 12 hours. If definite improvement is not noted within 48 hours after treatment the causal organism should be further investigated. Consult your veterinarian.
Milk out udder completely. Wash the udder and teats thoroughly with warm water containing a suitable dairy antiseptic and dry preferably using individual paper towels. Carefully scrub the teat end and orifice with 70% alcohol using a separate swab for each teat. Allow to dry.
ToDAY (cephapirin sodium) is packaged with the Opti-Sert® Protective Cap.
For partial insertion: Twist off upper portion of the Opti-Sert Protective Cap to expose 3-4 mm of the syringe tip.
For full insertion: Remove protective cap to expose the full length of the syringe tip.
Insert syringe tip into the teat canal and expel the entire contents of one syringe into each infected quarter. Withdraw the syringe and gently massage the quarter to distribute the suspension into the milk cistern. Do not milk out for 12 hours.
Do not infuse contents of the mastitis syringe into the teat canal if the Opti-Sert Protective Cap is broken or damaged.
Reinfection - The use of antibiotics however effective for the treatment of mastitis will not significantly reduce the incidence of this disease in the herd unless their use is fortified by good herd management and sanitary and mechanical safety measures are practiced to prevent reinfection. PRECAUTIONS
ToDAY should be administered with caution to subjects which have demonstrated some form of allergy particularly to penicillin. Such reactions are rare; however should they occur discontinue treatment and consult a veterinarian.  | RESIDUE WARNINGS- Milk that has been taken from animals during treatment and for 96 hours after the last treatment must not be used for food.
- Treated animals must not be slaughtered for food until 4 days after the last treatment.
- Administration of more than the prescribed dose may lead to residue of antibiotic in milk longer than 96 hours.
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