In cattle, administer either intramuscularly, intravenously or subcutaneously
for specific needs and duration; in swine, administer intramuscularly only.
Indications
Cattle:
In cattle, Oxytet 200 is indicated in the treatment of pneumonia and shipping
fever complex associated with Pasteurella spp. and Haemophilus spp.,
infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis,
footrot and diphtheria caused by Fusobacterium necrophorum, bacterial enteritis
(scours) caused by Escherichia coli, wooden tongue caused by Actinobacillus
lignieresi, leptospirosis caused by Leptospira pomona and wound infections and
acute metritis caused by strains of staphylococci and streptococci organisms sensitive
to oxytetracycline.
Swine:
In swine, Oxytet 200 is indicated for the treatment of bacterial enteritis (scours,
colibacillosis) caused by Escherichia coli, pneumonia caused by Pasteurella
multocida, and leptospirosis caused by Leptospira pomona. In sows, Oxytet 200
is also indicated as an aid in control of infectious enteritis (baby pig scours,
colibacillosis) in suckling pigs caused by Escherichia coli.
CAUTION
When administered to cattle, muscle discoloration may necessitate trimming of
the injection site(s) and surrounding tissues during the dressing procedure.
WARNING
Discontinue treatment at least 28 days prior to slaughter of cattle and swine.
Milk taken from animals during treatment and for 96 hours aft er the last treatment must not be used for food.
PRECAUTIONS
Exceeding the highest recommended level of drug per lb of body weight per day,
administering more than therecommended number of treatments, and/or exceeding
10 mL intramuscularly or subcutaneously per injection site in adult beef and dairy
cattle, and 5 mL intramuscularly per injection site in adult swine, may result
in antibiotic residues beyond the withdrawal period.
Reactions of an allergic or anaphylactic nature, sometimes fatal, have been
known to occur in hypersensitive animals following the injection of oxytetracycline.
Such adverse reactions can be characterized by signs such as restlessness, erection of hair, muscle trembling;
swelling of eyelids, ears, muzzle, anus, and vulva (or scrotum and sheath in
males); labored breathing, defecation and urination, glassy-eyed appearance, eruption of skin plaques,
frothing from the mouth, and prostration.
Pregnant animals that recover may subsequently abort. At the first sign of any
adverse reaction, discontinue use of this product and administer epinephrine
at the recommended dosage levels. Call a veterinarian immediately. Shock may be observed following
intravenous administration, especially where highly concentrated materials are
involved.
To minimize this occurrence, it is recommended that Oxytet 200 (200 mg/mL) be
administered slowly by this route.
Shortly after injection, treated animals may have transient hemoglobinuria
resulting in darkened urine. As with all antibiotic preparations, use of this
drug may result in overgrowth of nonsusceptible organisms, including fungi. A lack of
response by the treated animals, or the development of new signs, may suggest
that an overgrowth of nonsusceptible organisms has occurred. If any of these conditions occur,
consult your veterinarian. Since bacteriostatic drugs may interfere with the
bactericidal action of penicillin, it is advisable to avoid giving Oxytet 200
(200 mg/mL) in conjunction with penicillin.
STORAGE
Store at room temperature 15°-30°C (59°-86°F).
Keep from freezing.
CARE OF SICK ANIMALS
The use of antibiotics in the management of diseases is based on an accurate
diagnosis and an adequate course of treatment.
When properly used in the treatment of diseases caused bybeen treated with Oxytet
200 (200 mg/mL) show a noticeable improvement within 24-48 hours. It is recommended that the diagnosis and treatment
of animal diseases be carried out by a veterinarian. Since many diseases look alike but require diff erent types of
treatment, the use of professional veterinary and laboratory services can reduce treatment time, costs and needless losses. Good
housing, sanitation, and nutrition are important in the maintenance of healthy animals, and are essential in the treatment of
diseased animals.
DIRECTIONS FOR USE
Oxytet 200 (200 mg/mL) is intended for use in the treatment of disease due to
oxytetracycline-susceptible organisms in beef cattle; dairy cattle; calves; including preruminating (veal) calves; and
swine. A thoroughly cleaned, sterile needle and syringe should be used for each injection (needles and syringes may be sterilized
by boiling in water for 15 minutes).
In cold weather, Oxytet 200 (200 mg/mL) should be warmed to room temperature
before administration to animals. Before withdrawing the solution from the bottle, disinfect the rubber cap on
the bottle with suitable disinfectant, such as 70% alcohol. The injection site should be similarly cleaned with the disinfectant.
Needles of 16-18 gauge and 1-1Z\x inches long are adequate for intramuscular and subcutaneous injections. Needles
of 2-3 inches in length are recommended for intravenous use. | 
