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Ivomec Plus Injectable, 200 ml |  | 
Reg. $126.35 EACH
| | Product Details: | Merial
(1% w/v ivermectin and 10% w/v clorsulon in a sterile solution)
Injection for Cattle.
For the effective treatment and control of internal parasites including adult liver flukes and external parasites.
Consult your veterinarian for assistance in the diagnosis treatment and control of parasitism.
Introduction: The ability of IVOMEC® (ivermectin) to deliver internal and external parasite control has been proven in cattle markets around the world. Now Merial Limited combines ivermectin the active ingredient of IVOMEC with clorsulon an effective adult flukicide.
A single injection of IVOMEC Plus (ivermectin and clorsulon) offers all the benefits of IVOMEC plus control of adult Fasciola hepatica.
The dosage level of clorsulon supplied by IVOMEC Plus is effective only against adult liver flukes (Fasciola hepatica).
Product Description: IVOMEC Plus is a ready-to-use sterile solution containing 1% w/v ivermectin 10% clorsulon 40% glycerol formal and propylene glycol q.s. ad 100%. It is formulated to deliver the recommended dose level of 200 mcg ivermectin/kg and 2 mg clorsulon/kg given subcutaneously behind the shoulder at the rate of 1 mL per 110 lb (50 kg) body weight.
Mode of Action: Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).
The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.
Clorsulon is rapidly absorbed into the circulating blood. Erythrocytes with bound drug as well as plasma are ingested by Fasciola hepatica. Adult Fasciola hepatica are killed by clorsulon because of inhibition of enzymes in the glycolytic pathway which is their primary source of energy.
Indications:
IVOMEC Plus Injection is indicated for the effective treatment and control of the following parasites of cattle:
Gastrointestinal Roundworms (adults and fourth-stage larvae): Ostertagia ostertagi (including inhibited O. ostertagi) O. lyrata Haemonchus placei Trichostrongylus axei T. colubriformis Cooperia oncophora C. punctata C. pectinata Bunostomum phlebotomum Nematodirus helvetianus (adults only) N. spathiger (adults only) Oesophagostomum radiatum. Lungworms (adults and fourth-stage larvae): Dictyocaulus viviparus. Liver Flukes: Fasciola hepatica (adults only). Cattle Grubs (parasitic stages): Hypoderma bovis H. lineatum. Sucking Lice: Linognathus vituli Haematopinus eurysternus Solenopotes capillatus. Mange Mites (cattle scab*): Psoroptes ovis (syn. P. communis var. bovis) Sarcoptes scabiei var. bovis.
Precautions: Transitory discomfort has been observed in some cattle following subcutaneous administration. Soft-tissue swelling at the injection site has also been observed. These reactions have disappeared without treatment. divide doses greater than 10 mL between two injection sites to reduce occasional discomfort or site reaction. Different injection sites should be used for other parenteral products.
IVOMEC Plus Injection has been developed specifically for use in cattle only. This product should not be used in other animal species as severe adverse reactions including fatalities in dogs may result.
For subcutaneous injection in cattle only.
This product is not for intravenous or intramuscular use.
How Supplied:IVOMEC® Plus Injection is available in ready-to-use pack sizes: 200 ml. | | Cattle Supplies>Wormers
Sheep, Swine, Goats>Swine Supplies>Wormers
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