INDICATIONS:
For use in newborn foals as an aid in the prevention of colibacillosis and septicemia caused by K99 piliated Escherichia coli.

• Immediate Protection — Equine Coli Endotox goes to work immediately eliminating doubt that newborn foals ingested adequate levels of the antibody to ward off deadly E. coli.

• Broad Spectrum Effectiveness — Equine Coli Endotox provides protection against systemic E. coli infection (septicemia) in newborns. In studies conducted by research scientists at Novartis 100 percent of foals treated with Equine Coli Endotox were protected against death following severe E. coli challenge.

• Safe — Donor horses which generate the antibody in Equine Coli Endotox are routinely tested to be free of equine infectious anemia glanders brucellosis and equine viral arteritis.

DIRECTIONS:
Shake well before using. Administer 10 mL orally to foals less than 12 hours old. Slowly syringe towardthe back of the foal"s mouth. Colostrum should be fed to each foal.

PRECAUTIONS:
Store out of direct sunlight at 2°-7° C (35°-45° F). DO NOT FREEZE. Use entire contents when first opened. Anaphylactic reactions may occur. Symptomatic treatment: Epinephrine. Contains oxytetracycline phenol and thimerosal as preservatives.

TECHNICAL DISEASE INformATION:Endotoxemia septicemia and enteric infections are the most severe problems affecting neonatal foals often ulminating in death. Approximately 25 percent of all septicemias in foals are caused by Escherichia coli. nvasive strains of this bacteria enter the foal's bloodstream either through the intestinal tract the respiratory tract or the umbilical cord. Bacteria begin to circulate throughout the body releasing toxins and causing symptoms such as lethargy depression anorexia and sudden death. Septicemia in foals often results in chronic arthritis since the bacteria tend to take refuge in the joint cavities where they are difficult to reach with antibiotics. Foals with E. coli infection may also show diarrhea but this is less common than in other species such as calves and piglets.

The most common factor predisposing foals to developing E. coli septicemia is hypogammaglobulinemia (inadequate levels of passive antibody protection from the mare's colostrum). This is caused by several factors such as foals failing to nurse adequately poor quality colostrum in the mare or loss of colostrum prior to foaling in mares that leak milk. Up until now measures to combat this problem were limited to complex procedures such as blood transfusions from mare to foal or obtaining colostrum from another mare to feed to the foal. Since a foal is often not recognized as being hypogammaglobulinemic until it becomes sick treatment is often ineffective.

Equine Coli Endotox is not a replacement for colostrum. Colostrum contains components that are necessary or the total health of the foal. Good management practices are necessary to ensure adequate colostral intake by the foal. Since many foals do not receive protective passive immunity and many are born in an environment highly contaminated with E. coli organisms they often lack adequate ability to fight septicemia caused by E. coli. One dose of Equine Coli Endotox given orally to the newborn foal provides a safe easy effective method of giving the foal specific passive antibodies it needs to help ward off E. coli infections that can be deadly. See table 1.

The above trial clearly illustrates the importance of including Equine Coli Endotox in a routine foal health rogram.The postchallenge mortality in non-treated controls exceeded 70 percent while no deaths occurred in the treatment group. In addition a 12-fold reduction in clinical scores was seen in the treatment group which reflects protective capabilities achieved from using Equine Coli Endotox.