Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine Modified Live Virus

Description: Bovi-Shield 4 is a freeze-dried preparation of modified live virus (MLV) strains of IBR BVD PI3 and BRSV viruses plus a sterile diluent used to rehydrate the freeze-dried vaccine. Viral antigens are propagated on established cell lines.Contains gentamicin as preservative.Indications: Bovi-Shield 4 is for vaccination of healthy nonpregnant cattle as an aid in preventing infectious bovine rhinotracheitis caused by infectious bovine rhinotracheitis (IBR) virus bovine viral diarrhea (Type 1 and Type 2) caused by bovine viral diarrhea (BVD) virus and disease caused by parainfluenza3 (PI3) virus and bovine respiratory syncytial virus (BRSV).Directions:
1. General Directions: Vaccination of healthy nonpregnant cattle is recommended. Aseptically rehydrate the freeze-dried vaccine with the sterile diluent provided shake well and administer 2mL intramuscularly. In accordance with Beef Quality Assurance guidelines this product should be administered in the muscular region of the neck.
2. Primary Vaccination: Administer a single 2 mL dose to healthy cattle followed by a second dose of Bovi-Shield BRSV 3-4 weeks later.
3. Revaccination: Annual revaccination with a single dose is recommended.
4. Good animal husbandry and herd health management practices should be employed.
Precaution(s): Store at 2°-7°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze.
Use entire contents when first opened.
Sterilized syringes and needles should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine.
Burn containers and all unused contents.
Caution(s): Do not use in pregnant cows (abortions can result) or in calves nursing pregnant cows.
As with many vaccines anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.
This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are incubating an infectious disease are malnourished or parasitized are stressed due to shipment or environmental conditions are otherwise immunocompromised or the vaccine is not administered in accordance with label directions.
Warning(s): Do not vaccinate within 21 days before slaughter.
For veterinary use only.
Discussion: Disease Description: IBR BVD PI3 and BRSV viruses are commonly associated with respiratory disease and/or reproductive failure in cattle. IBR virus infection is characterized by high temperature excessive nasal discharge conjunctivitis and ocular discharge inflamed nose ( red nose ) increased rate of respiration coughing loss of appetite and depression. Cattle infected during pregnancy may abort.
BVD virus may be transmitted in nasal secretions saliva blood feces and/or urine and by direct contact with contaminated objects; it invades through the nose and mouth and replicates systemically. Infection during pregnancy may result in abortion fetal resorption or congenital malformation of the fetus. Moreover if susceptible cows are infected with noncytopathic BVD virus during the first trimester of pregnancy their calves may be born persistently infected with the virus. Exposure of those calves to certain virulent cytopathic BVD virus strains may precipitate BVD-mucosal disease. Clinical signs of BVD include loss of appetite ulcerations in the mouth profuse salivation elevated temperature diarrhea dehydration and lameness.PI3 virus usually localizes in the upper respiratory tract causing elevated temperature and moderate nasal and ocular discharge. Although clinical signs typically are mild PI3 infection weakens respiratory tissues. Invasion and replication of other pathogens particularly Pasteurella spp. is thereby facilitated and may result in pneumonia.BRSV is the etiologic agent of a specific viral respiratory disease of cattle of all ages including nursing calves. Infection is characterized by rapid breathing coughing loss of appetite discharge from the nose and eyes fever and swelling around the throat and neck. In an acute outbreak deaths may follow within 48 hours after onset of signs. Clinically BRSV infection may be indistinguishable from other viral infections associated with the bovine respiratory disease complex. BRSV infection like PI3 facilitates invasion and replication of other respiratory pathogens. Exacerbation of clinical signs has been documented when concurrent BRSV and BVD or IBR infection exists.
Presentation: 50 dose.